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Beneficial
effects of growth
hormone treatment in human growth hormone-deficient adults.
Jorgensen JO, Pedersen SA, Thuesen L, Jorgensen J,
Ingemann-Hansen T, Skakkebaek NE, Christiansen JS.
Second University Clinic of Internal Medicine, Aarhus
Kommunehospital, Denmark.
A
double-blind, placebo-controlled, crossover
study on the effects of 4 months' human
growth hormone (GH) treatment was carried out
in 22 GH-deficient adults (8 women, 14 men; mean
[SEM] age 23.8 [1.2] years). 1 patient was withdrawn
because of oedema. Mean total body weight of the
other 21 did not change, whereas mean muscle volume
of the thigh, estimated by computerised tomography
(CT), was significantly higher after GH than after
placebo (70.0 [3.7] vs 66.3 [3.1] ml/0.8 cm cross-sectional
slice). The mean adipose tissue volume of the thigh
and subscapular skinfold thickness fell significantly
during GH treatment.
Growth
hormone caused a small increase in
the isometric strength of the quadriceps muscles
and a significant rise in exercise capacity (60.8
[7.2] vs 54.2 [6.6] kJ). The heart rate both at
rest and after maximum exercise was low during
the placebo period and increased significantly
during GH treatment. Blood pressure and echocardiographic
wall mass of the left ventricle did not change
during the study.
Growth
hormone increased both mean glomerular
filtration rate and renal plasma flow from a
subnormal level on placebo to a level comparable
with that of an age-matched control group. The
filtration fraction did not change. Urinary
albumin excretion was in the low normal range
and was not affected by GH treatment.
Finally,
human growth hormone treatment normalised mean circulating
levels of insulin-like growth factor 1 (IGF-1),
which were low after the placebo period (96
[9] micrograms/l placebo; 224 [28] micrograms/l
GH). These findings suggest that GH, in a
conventional replacement dose, has several
potentially beneficial effects in GH-deficient
adults and therefore encourage future long-term
trials.
Publication
Types: Clinical Trial Randomized
Controlled Trial PMID: 2566779 [PubMed -
indexed for MEDLINE]
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