Growth hormone, at the relatively low dose of 0.003 mg/kg was shown to normalize lean body mass over 6 months in 24 adults with human growth hormone deficiency (1). The improvement in lean body mass is associated with increased protein synthesis, muscle mass and muscle function. Total body fat mass also decreases after 6 months of human growth hormone administration. The decline in fat mass is most significant in visceral and trunk locations as compared to the arms, neck and legs, suggesting that GH replacement therapy will reverse the truncal redistribution of fat mass associated with human growth hormone deficiency and impact on cardiovascular risk (6).