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Antiaging Article
(2). Muscle mass
and muscle strength are diminished in human growth hormone-deficient
patients. In the heart, these changes are manifested by a reduced left ventricular
mass, decreased fractional shortening of cardiac myocytes, and decreased cardiac
output. Such abnormalities may contribute to the striking decline in exercise
capacity in this population. In one recent study, exercise capacity, as assessed
by cycle ergometry was decreased by 20-25% compared to normal controls
(3).
Bone density is also known to be reduced in the human growth hormone
-deficient patient. In a recent study, cortical bone density and spinal (trabecular)
bone density were 2.8 and 1.5 standard deviations below the mean for age and sex
matched controls
(4).
Finally, patients with GH deficiency appear to have impaired psychological
well being and potentially significant neuropsychiatric manifestations, such as
lack of concentration and memory impairment. Self rating questionnaires consistently
demonstrate reduced vitality, fatigue, social isolation and depression (5).
However,
it is unknown whether this impairment in psychological well being is
associated specifically with GH deficiency or is due to another factor associated
with hypopituitarism. Recombinant Human Growth Hormone Therapy Recombinant human
growth hormone may become a novel therapeutic option for adults with acquired
human growth hormone deficiency. Recent studies indicate that many of the metabolic
and psychological abnormalities associated with GH deficiency can be reversed
with GH replacement, even at low doses which are not associated with side effects.
Body Composition human growth hormone therapy results in profound changes in body
composition: fat mass is reduced while lean body mass increases.
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