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Acquired
human growth hormone (HGH)
deficiency results from the destruction of normal
pituitary and/or hypothalamic tissue, usually from
a tumor or secondary to surgical and/or radiation
therapy.
Diagnostic
criteria and clinical sequelae of HGH deficiency,
although well established in children, are currently
areas of active investigation in the adult. It is
now apparent that acquired human growth hormone
deficiency is associated with significant changes
in body composition, bone density, lipid metabolism,
cardiovascular function and physical performance.
In addition, new information is now available on
the use of low doses of recombinant human growth
hormone (rhGH)
to reverse the sequelae of GH deficiency in adults.
The
Human Growth Hormone Deficiency Syndrome:
Acquired
human growth hormone deficiency is characterized by weight gain, increased
fat mass and decreased lean body mass. In one recent study, total body fat was
shown to be increased by 7% in this population while lean body mass was decreased
to a similar degree (1).
The
increased fat mass is found in a truncal
distribution, thereby increasing the
waist:hip ratio. In addition, triglyceride
levels are increased and HDL levels decreased.
The increased lipid levels may explain,
in part, the observation of increased vascular
wall thickness, as measured by carotid ultrasonography,
in this population. These factors all likely
contribute to the increased incidence of
cardiovascular mortality seen in patients
with GH deficiency.
When
looking for products for anti-aging and
longevity, Hgh Plus™
is the name that consistently shows up as
being the most effective, safe and useful
for the widest range of individuals.
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